CARDIOVASCULAR PHYSIOLOGY DURING PREGNANCY - ELECTROPHYSIOLOGY



If a is introduced into a single , an action potential (Fig. 1-9) can be recorded by measuring the potential difference between the inside and the outside of the cell (inside negative). The of a normal is approximately - 90 millivolts (mv) with respect to the outside of the cell. When the membrane potential is depolarized to a certain , an action potential occurs with a rapid (phase 0); a return toward zero from the initial overshoot or early rapid (phase 1); a plateau (phase 2); final rapid (); and and ” diastolic depolarization (phase 4). The normal is maintained by the active (i.e., energy-requiring) exclusion of sodium and the accumulation of potassium inside the cell. Phase 0 or rapid depolarization is due chiefly to the opening of the sarcolemmal channels to sodium entrance in atrial and ventricular muscle and cells in the His-. Calcium is important in the maintenance of the action potential plateau of fast

Action potentials recorded from different tissues in the heart remounted with a His bundle recording and scalar ECG from a patient to illustrate the timing during a single . SN = Sinus nodal potential; A = atrial muscle potential; AVN = atrioventricular nodal potential; PF = Purkinje fiber potential; V = ventricular muscle potential; HB = His bundle recording; II = lead II. The A-H interval measured in the His bundle recording approximates AV nodal conduction time, and the H-V interval approximates His- conduction time.

sodium channeldependent cells and in the generation of the action potential in slow calcium channeldependent cells such as the sinus and AV nodes. is mediated chiefly by an outward potassium current, and the membrane returns to its negative during electrical diastole. is a property of some cardiac tissues to undergo gradual phase 4 depolarization spontaneously until threshold potential is reached and the cell initiates an action potential that is propagated from one cell to another. Normal is present in sinus nodal tissue, some atrial and junctional tissues, the bundle branches, and Purkinje fibers. The sinus node discharges more rapidly than the other cells and is the normal pacemaker of the heart. Conduction is the propagation of a cardiac impulse and is most closely influenced by the amplitude and velocity of phase 0 of the action potential. Refractoriness is a property of cardiac tissue during which a stimulus occurring soon after a previous action potential fails to elicit another normal action potential; it is most closely related to the duration of of the cardiac action potential in most tissues.

The genesis of the normal electrocardiogram is from electrical activity recorded by skin electrodes that is the sum of all the cardiaC action potentials of its component cells. The P wave represents atrial depolarization. The PR interval is a measure of the time necessary to travel from the sinus node through the atrium, AV node, and His- to activate ventricular myocardial cells. The QRS complex represents the sum of all ventricular muscle cell depolarizations (phase 0), the ST segment represents the , and the T wave represents the rapid re­polarization () of the heart as a whole.

Although the autonomic nervous system may affect atrial and ventricular tissue to a small extent, the most prominent autonomic effects are observed on the sinus and the AV nodes. Sympathetic stimulation increases the rate of and increases conduction velocity, whereas parasympathetic (vagal) activation does the opposite. Baroreceptors in the carotid sinus, located at the bifurcation of the internal and external carotid arteries, activate the vagus nerve when blood pressure increases and reflexively decrease heart rate and AV nodal conduction velocity.




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